Design, synthesis, docking, MD simulations, and anti-proliferative evaluation of thieno[2,3-d]pyrimidine derivatives as new EGFR inhibitors

A group of EGFR inhibitors derived from thieno[2,3-d]pyrimidine nucleus was designed, synthesised, and examined as anti-proliferative lead compounds. MCF-7 and A549 cell lines were inhibited by 5b, the most active member. It had inhibitory partialities of 37.19 and 204.10 nM against EGFR(WT) and EGF...

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Detalles Bibliográficos
Autores principales: Sobh, Eman A., Dahab, Mohammed A., Elkaeed, Eslam B., Alsfouk, Aisha A., Ibrahim, Ibrahim M., Metwaly, Ahmed M., Eissa, Ibrahim H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251802/
https://www.ncbi.nlm.nih.gov/pubmed/37288786
http://dx.doi.org/10.1080/14756366.2023.2220579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251802/
https://www.ncbi.nlm.nih.gov/pubmed/37288786
http://dx.doi.org/10.1080/14756366.2023.2220579

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