Therapeutic Potential of a Small-Molecule STAT3 Inhibitor in a Mouse Model of Colitis

SIMPLE SUMMARY: We used the dextran sodium sulfate (DSS) murine model of colitis, which is widely used in preclinical studies, to determine the contribution of STAT3 to IBD. STAT3 has two isoforms: (STAT3α; which has pro-inflammatory and anti-apoptotic functions, and STAT3β; which attenuates the eff...

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Detalles Bibliográficos
Autores principales: Robinson, Prema, Montoya, Kelsey, Magness, Emily, Rodriguez, Emma, Villalobos, Viviana, Engineer, Nikita, Yang, Peng, Bharadwaj, Uddalak, Eckols, Thomas Kris, Tweardy, David John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251885/
https://www.ncbi.nlm.nih.gov/pubmed/37296943
http://dx.doi.org/10.3390/cancers15112977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251885/
https://www.ncbi.nlm.nih.gov/pubmed/37296943
http://dx.doi.org/10.3390/cancers15112977

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