Autotaxin Inhibition with IOA-289 Decreases Breast Tumor Growth in Mice Whereas Knockout of Autotaxin in Adipocytes Does Not

SIMPLE SUMMARY: Breast cancer cells produce negligible quantities of autotaxin. We hypothesized that the autotaxin produced by inflamed breast adipocytes adjacent to breast tumors provides a major source of autotaxin secretion that drives breast tumor progression and the loss of treatment efficacy....

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Detalles Bibliográficos
Autores principales: Tang, Xiaoyun, Morris, Andrew J., Deken, Marcel A., Brindley, David N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251959/
https://www.ncbi.nlm.nih.gov/pubmed/37296899
http://dx.doi.org/10.3390/cancers15112937

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10251959/
https://www.ncbi.nlm.nih.gov/pubmed/37296899
http://dx.doi.org/10.3390/cancers15112937

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