Polygenic Risk Score Predicts Modified Risk in BRCA1 Pathogenic Variant c.4035del and c.5266dup Carriers in Breast Cancer Patients

SIMPLE SUMMARY: The objective of our study was to explore the potential of using a polygenic risk score (PRS) to estimate the overall genetic risk of developing breast or ovarian cancer for women with inherited BRCA1 pathogenic variants. We applied a previously developed PRS to 406 women with germli...

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Detalles Bibliográficos
Autores principales: Berga-Švītiņa, Egija, Maksimenko, Jeļena, Miklaševičs, Edvīns, Fischer, Krista, Vilne, Baiba, Mägi, Reedik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252024/
https://www.ncbi.nlm.nih.gov/pubmed/37296919
http://dx.doi.org/10.3390/cancers15112957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252024/
https://www.ncbi.nlm.nih.gov/pubmed/37296919
http://dx.doi.org/10.3390/cancers15112957

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