Extracellular Vesicles Released by Genetically Modified Macrophages Activate Autophagy and Produce Potent Neuroprotection in Mouse Model of Lysosomal Storage Disorder, Batten Disease

Over the recent decades, the use of extracellular vesicles (EVs) has attracted considerable attention. Herein, we report the development of a novel EV-based drug delivery system for the transport of the lysosomal enzyme tripeptidyl peptidase-1 (TPP1) to treat Batten disease (BD). Endogenous loading...

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Detalles Bibliográficos
Autores principales: El-Hage, Nazira, Haney, Matthew J., Zhao, Yuling, Rodriguez, Myosotys, Wu, Zhanhong, Liu, Mori, Swain, Carson J., Yuan, Hong, Batrakova, Elena V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252192/
https://www.ncbi.nlm.nih.gov/pubmed/37296618
http://dx.doi.org/10.3390/cells12111497

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252192/
https://www.ncbi.nlm.nih.gov/pubmed/37296618
http://dx.doi.org/10.3390/cells12111497

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