Targeting Stage-Specific Embryonic Antigen 4 (SSEA-4) in Triple Negative Breast Cancer by CAR T Cells Results in Unexpected on Target/off Tumor Toxicities in Mice

Due to the paucity of targetable antigens, triple-negative breast cancer (TNBC) remains a challenging subtype of breast cancer to treat. In this study, we developed and evaluated a chimeric antigen receptor (CAR) T cell-based treatment modality for TNBC by targeting stage-specific embryonic antigen...

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Detalles Bibliográficos
Autores principales: Pfeifer, Rita, Al Rawashdeh, Wa’el, Brauner, Janina, Martinez-Osuna, Manuel, Lock, Dominik, Herbel, Christoph, Eckardt, Dominik, Assenmacher, Mario, Bosio, Andreas, Hardt, Olaf T., Johnston, Ian C. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252441/
https://www.ncbi.nlm.nih.gov/pubmed/37298141
http://dx.doi.org/10.3390/ijms24119184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252441/
https://www.ncbi.nlm.nih.gov/pubmed/37298141
http://dx.doi.org/10.3390/ijms24119184

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