Cargando…

Palbociclib-Induced Cellular Senescence Is Modulated by the mTOR Complex 1 and Autophagy

Despite not dividing, senescent cells acquire the ability to synthesize and secrete a plethora of bioactive molecules, a feature known as the senescence-associated secretory phenotype (SASP). In addition, senescent cells often upregulate autophagy, a catalytic process that improves cell viability in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cayo, Angel, Venturini, Whitney, Rebolledo-Mira, Danitza, Moore-Carrasco, Rodrigo, Herrada, Andrés A., Nova-Lamperti, Estefanía, Valenzuela, Claudio, Brown, Nelson E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252531/ https://www.ncbi.nlm.nih.gov/pubmed/37298236 http://dx.doi.org/10.3390/ijms24119284

Ejemplares similares

mTOR Activity and Autophagy in Senescent Cells, a Complex Partnership
por: Cayo, Angel, et al.
Publicado: (2021)

SASP-Dependent Interactions between Senescent Cells and Platelets Modulate Migration and Invasion of Cancer Cells
por: Valenzuela, Claudio A., et al.
Publicado: (2019)

Platelet Activation Is Triggered by Factors Secreted by Senescent Endothelial HMEC-1 Cells In Vitro
por: Venturini, Whitney, et al.
Publicado: (2020)

Platelets, a Key Cell in Inflammation and Atherosclerosis Progression
por: Huilcaman, Ricardo, et al.
Publicado: (2022)

mTOR, autophagy, and reprogramming
por: Tang, Bor Luen
Publicado: (2014)

mTOR‐autophagy promotes pulmonary senescence through IMP1 in chronic toxicity of methamphetamine
por: Zhu, Mei‐Jia, et al.
Publicado: (2020)

mTOR Pathways in Cancer and Autophagy
por: Paquette, Mathieu, et al.
Publicado: (2018)

HMGA1 augments palbociclib efficacy via PI3K/mTOR signaling in intrahepatic cholangiocarcinoma
por: Li, Zhipeng, et al.
Publicado: (2023)

Dissecting the role of mTOR complexes in cellular senescence
por: Serrano, Manuel
Publicado: (2012)

The Potential Role of Senescence As a Modulator of Platelets and Tumorigenesis
por: Valenzuela, Claudio A., et al.
Publicado: (2017)

The mTOR–Autophagy Axis and the Control of Metabolism
por: Deleyto-Seldas, Nerea, et al.
Publicado: (2021)

Hypoxia, MTOR and autophagy: Converging on senescence or quiescence
por: Blagosklonny, Mikhail V.
Publicado: (2013)

Reversal of phenotypes of cellular senescence by pan-mTOR inhibition
por: Walters, Hannah E., et al.
Publicado: (2016)

Autophagy termination and lysosome reformation regulated by mTOR
por: Yu, Li, et al.
Publicado: (2010)

mTOR's role in ageing: protein synthesis or autophagy?
por: Hands, Sarah L., et al.
Publicado: (2009)

mTOR, AMBRA1, and autophagy: An intricate relationship
por: Nazio, Francesca, et al.
Publicado: (2013)

The Role of AKT/mTOR Pathway in Stress Response to UV-Irradiation: Implication in Skin Carcinogenesis by Regulation of Apoptosis, Autophagy and Senescence
por: Strozyk, Elwira, et al.
Publicado: (2013)

High glucose and palmitic acid induces neuronal senescence by NRSF/REST elevation and the subsequent mTOR-related autophagy suppression
por: Xue, Wen-Jiao, et al.
Publicado: (2022)

Curcumin Alleviates D-Galactose-Induced Cardiomyocyte Senescence by Promoting Autophagy via the SIRT1/AMPK/mTOR Pathway
por: Yang, Lei, et al.
Publicado: (2022)

mTOR Overactivation and Compromised Autophagy in the Pathogenesis of Pulmonary Fibrosis
por: Gui, Yao-Song, et al.
Publicado: (2015)

Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson’s Disease
por: Zhu, Zhou, et al.
Publicado: (2019)

Pleiotropic Effects of mTOR and Autophagy During Development and Aging
por: Schmeisser, Kathrin, et al.
Publicado: (2019)

The Upstream Pathway of mTOR-Mediated Autophagy in Liver Diseases
por: Wang, Haojie, et al.
Publicado: (2019)

mTORC2: The other mTOR in autophagy regulation
por: Ballesteros‐Álvarez, Josué, et al.
Publicado: (2021)

Celastrol promotes chondrocyte autophagy by regulating mTOR expression
por: Dai, Siming, et al.
Publicado: (2022)

Role of mTOR through Autophagy in Esophageal Cancer Stemness
por: Du, Liang, et al.
Publicado: (2022)

Palbociclib resistance confers dependence on an FGFR-MAP kinase-mTOR-driven pathway in KRAS-mutant non-small cell lung cancer
por: Haines, Eric, et al.
Publicado: (2018)

mTOR favors senescence over quiescence in p53-arrested cells
por: Schug, Thaddeus T.
Publicado: (2010)

mTOR signaling orchestrates the expression of cytoprotective factors during cellular senescence
por: Yosef, Reut, et al.
Publicado: (2016)

Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity
por: Pogacar, Ziva, et al.
Publicado: (2022)

mTOR-Controlled Autophagy Requires Intracellular Ca(2+) Signaling
por: Decuypere, Jean-Paul, et al.
Publicado: (2013)

Regulation of Autophagy in Chick Skeletal Muscle: Effect of mTOR Inhibition
por: Nakashima, Kazuki, et al.
Publicado: (2020)

Autophagy and mTOR signaling during intervertebral disc aging and degeneration
por: Yurube, Takashi, et al.
Publicado: (2020)

Hirudin inhibits glioma growth through mTOR‐regulated autophagy
por: Ma, Ying, et al.
Publicado: (2023)

Melatonin Rescues Mesenchymal Stem Cells from Senescence Induced by the Uremic Toxin p-Cresol via Inhibiting mTOR-Dependent Autophagy
por: Yun, Seung Pil, et al.
Publicado: (2018)

Cordycepin inhibits cell senescence by ameliorating lysosomal dysfunction and inducing autophagy through the AMPK and mTOR–p70S6K pathway
por: Zuo, Shi Qi, et al.
Publicado: (2021)

Keratoacanthoma of the Lip: Activation of the mTOR Pathway, Tumor Suppressor Proteins, and Tumor Senescence
por: Dillenburg, Caroline Siviero, et al.
Publicado: (2015)

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
por: Herranz, Nicolás, et al.
Publicado: (2015)

Individual response to mTOR inhibition in delaying replicative senescence of mesenchymal stromal cells
por: Antonioli, Eliane, et al.
Publicado: (2019)

Role of mTOR in the Development of Asthma in Mice With Cigarette Smoke-Induced Cellular Senescence
por: Lee, Hyun Seung, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_94r3pt1aohcbah0oerlkn5bi2a