Reversal of Tau-Dependent Cognitive Decay by Blocking Adenosine A1 Receptors: Comparison of Transgenic Mouse Models with Different Levels of Tauopathy

The accumulation of tau is a hallmark of several neurodegenerative diseases and is associated with neuronal hypoactivity and presynaptic dysfunction. Oral administration of the adenosine A(1) receptor antagonist rolofylline (KW-3902) has previously been shown to reverse spatial memory deficits and t...

Descripción completa

Detalles Bibliográficos
Autores principales: Anglada-Huguet, Marta, Endepols, Heike, Sydow, Astrid, Hilgers, Ronja, Neumaier, Bernd, Drzezga, Alexander, Kaniyappan, Senthilvelrajan, Mandelkow, Eckhard, Mandelkow, Eva-Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252552/
https://www.ncbi.nlm.nih.gov/pubmed/37298211
http://dx.doi.org/10.3390/ijms24119260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252552/
https://www.ncbi.nlm.nih.gov/pubmed/37298211
http://dx.doi.org/10.3390/ijms24119260

Ejemplares similares