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Reversal of Tau-Dependent Cognitive Decay by Blocking Adenosine A1 Receptors: Comparison of Transgenic Mouse Models with Different Levels of Tauopathy

The accumulation of tau is a hallmark of several neurodegenerative diseases and is associated with neuronal hypoactivity and presynaptic dysfunction. Oral administration of the adenosine A(1) receptor antagonist rolofylline (KW-3902) has previously been shown to reverse spatial memory deficits and t...

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Detalles Bibliográficos
Autores principales:	Anglada-Huguet, Marta, Endepols, Heike, Sydow, Astrid, Hilgers, Ronja, Neumaier, Bernd, Drzezga, Alexander, Kaniyappan, Senthilvelrajan, Mandelkow, Eckhard, Mandelkow, Eva-Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252552/ https://www.ncbi.nlm.nih.gov/pubmed/37298211 http://dx.doi.org/10.3390/ijms24119260

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