SAM-Competitive EZH2-Inhibitors Induce Platinum Resistance by EZH2-Independent Induction of ABC-Transporters

SIMPLE SUMMARY: The histone lysine methyltransferase EZH2 is frequently altered in lymphoid tumors. Its overexpression or mutation is associated with tumor progression and resistance to chemotherapy. This makes it an attractive target for inhibition especially in combination treatments with establis...

Descripción completa

Detalles Bibliográficos
Autores principales: Groß, Elisabeth, Hilger, Ralf-Axel, Schümann, Franziska Lea, Bauer, Marcus, Bouska, Alyssa, Rohde, Christian, Willscher, Edith, Lützkendorf, Jana, Müller, Lutz Peter, Edemir, Bayram, Mueller, Thomas, Herling, Marco, Binder, Mascha, Wickenhauser, Claudia, Iqbal, Javeed, Posern, Guido, Weber, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252553/
https://www.ncbi.nlm.nih.gov/pubmed/37297005
http://dx.doi.org/10.3390/cancers15113043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252553/
https://www.ncbi.nlm.nih.gov/pubmed/37297005
http://dx.doi.org/10.3390/cancers15113043

Ejemplares similares