Structure-Guided Design of N-Methylpropargylamino-Quinazoline Derivatives as Multipotent Agents for the Treatment of Alzheimer’s Disease

Alzheimer’s disease (AD) is a complex disease with an unknown etiology. Available treatments, limited to cholinesterase inhibitors and N-methyl-d-aspartate receptor (NMDAR) antagonists, provide symptomatic relief only. As single-target therapies have not proven effective, rational specific-targeted...

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Detalles Bibliográficos
Autores principales: Svobodova, Barbora, Pulkrabkova, Lenka, Panek, Dawid, Misiachna, Anna, Kolcheva, Marharyta, Andrys, Rudolf, Handl, Jiri, Capek, Jan, Nyvltova, Pavlina, Rousar, Tomas, Prchal, Lukas, Hepnarova, Vendula, Hrabinova, Martina, Muckova, Lubica, Tosnerova, Daniela, Karabanovich, Galina, Finger, Vladimir, Soukup, Ondrej, Horak, Martin, Korabecny, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252614/
https://www.ncbi.nlm.nih.gov/pubmed/37298087
http://dx.doi.org/10.3390/ijms24119124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10252614/
https://www.ncbi.nlm.nih.gov/pubmed/37298087
http://dx.doi.org/10.3390/ijms24119124

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