Corneal Edema in Inducible Slc4a11 Knockout Is Initiated by Mitochondrial Superoxide Induced Src Kinase Activation

Purpose: Inducible Slc4a11 KO leads to corneal edema by disruption of the pump and barrier functions of the corneal endothelium (CE). The loss of Slc4a11 NH(3)-activated mitochondrial uncoupling leads to mitochondrial membrane potential hyperpolarization-induced oxidative stress. The goal of this st...

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Detalles Bibliográficos
Autores principales: Ogando, Diego G., Kim, Edward T., Li, Shimin, Bonanno, Joseph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253072/
https://www.ncbi.nlm.nih.gov/pubmed/37296649
http://dx.doi.org/10.3390/cells12111528

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253072/
https://www.ncbi.nlm.nih.gov/pubmed/37296649
http://dx.doi.org/10.3390/cells12111528

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