α-Tocopherol-13′-Carboxychromanol Induces Cell Cycle Arrest and Cell Death by Inhibiting the SREBP1-SCD1 Axis and Causing Imbalance in Lipid Desaturation

α-Tocopherol-13′-carboxychromanol (α-T-13′-COOH) is an endogenously formed bioactive α-tocopherol metabolite that limits inflammation and has been proposed to exert lipid metabolism-regulatory, pro-apoptotic, and anti-tumoral properties at micromolar concentrations. The mechanisms underlying these c...

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Detalles Bibliográficos
Autores principales: Liao, Sijia, Gollowitzer, André, Börmel, Lisa, Maier, Charlotte, Gottschalk, Luisa, Werz, Oliver, Wallert, Maria, Koeberle, Andreas, Lorkowski, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253185/
https://www.ncbi.nlm.nih.gov/pubmed/37298183
http://dx.doi.org/10.3390/ijms24119229

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253185/
https://www.ncbi.nlm.nih.gov/pubmed/37298183
http://dx.doi.org/10.3390/ijms24119229

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