CRISPR/Cas9 Knock-Out in Primary Neonatal and Adult Cardiomyocytes Reveals Distinct cAMP Dynamics Regulation by Various PDE2A and PDE3A Isoforms

Cyclic nucleotide phosphodiesterases 2A (PDE2A) and PDE3A play an important role in the regulation of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP)-to-cAMP crosstalk. Each of these PDEs has up to three distinct isoforms. However, their specific contributions to cAMP...

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Detalles Bibliográficos
Autores principales: Skryabin, Egor B., De Jong, Kirstie A., Subramanian, Hariharan, Bork, Nadja I., Froese, Alexander, Skryabin, Boris V., Nikolaev, Viacheslav O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253201/
https://www.ncbi.nlm.nih.gov/pubmed/37296663
http://dx.doi.org/10.3390/cells12111543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253201/
https://www.ncbi.nlm.nih.gov/pubmed/37296663
http://dx.doi.org/10.3390/cells12111543

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