Cargando…

Investigating the Role of Heparanase in Breast Cancer Development Utilising the MMTV-PyMT Murine Model of Mammary Carcinoma

SIMPLE SUMMARY: Heparanase (HPSE) has been demonstrated to enhance the progression and metastasis of solid tumours, leading to a poor clinical prognosis. However, robust genetic ablation animal models to investigate the role of HPSE in breast cancer have not been described. The aim of this study was...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jayatilleke, Krishnath M., Duivenvoorden, Hendrika M., Ryan, Gemma F., Parker, Belinda S., Hulett, Mark D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253202/ https://www.ncbi.nlm.nih.gov/pubmed/37297024 http://dx.doi.org/10.3390/cancers15113062

Ejemplares similares

Deletion of Cd151 reduces mammary tumorigenesis in the MMTV/PyMT mouse model
por: Roselli, Séverine, et al.
Publicado: (2014)

Transcriptomic dynamics of breast cancer progression in the MMTV-PyMT mouse model
por: Cai, Ying, et al.
Publicado: (2017)

MRCKα Is Dispensable for Breast Cancer Development in the MMTV-PyMT Model
por: Kwa, Mei Qi, et al.
Publicado: (2021)

A PDE Model of Breast Tumor Progression in MMTV-PyMT Mice
por: Mohammad Mirzaei, Navid, et al.
Publicado: (2022)

Heparanase and the hallmarks of cancer
por: Jayatilleke, Krishnath M., et al.
Publicado: (2020)

Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice
por: Decock, Julie, et al.
Publicado: (2015)

Interplay between CCR7 and Notch1 axes promotes stemness in MMTV-PyMT mammary cancer cells
por: Boyle, Sarah T., et al.
Publicado: (2017)

Apc Mutation Enhances PyMT-Induced Mammary Tumorigenesis
por: Prosperi, Jenifer R., et al.
Publicado: (2011)

Biomarkers of Residual Disease, Disseminated Tumor Cells, and Metastases in the MMTV-PyMT Breast Cancer Model
por: Franci, Christian, et al.
Publicado: (2013)

High-Fat, High-Calorie Diet Enhances Mammary Carcinogenesis and Local Inflammation in MMTV-PyMT Mouse Model of Breast Cancer
por: Cowen, Sarah, et al.
Publicado: (2015)

Cholesteryl Ester Promotes Mammary Tumor Growth in MMTV-PyMT Mice and Activates Akt-mTOR Pathway in Tumor Cells
por: Wei, Lengyun, et al.
Publicado: (2021)

Early vascular deficits are correlated with delayed mammary tumorigenesis in the MMTV-PyMT transgenic mouse following genetic ablation of the NG2 proteoglycan
por: Gibby, Krissa, et al.
Publicado: (2012)

The chemokine receptor CCR6 facilitates the onset of mammary neoplasia in the MMTV-PyMT mouse model via recruitment of tumor-promoting macrophages
por: Boyle, Sarah T., et al.
Publicado: (2015)

Treatment response assessment with (R)-[(11)CPAQ PET in the MMTV-PyMT mouse model of breast cancer
por: Tegnebratt, T., et al.
Publicado: (2018)

A Milk-Fat Based Diet Increases Metastasis in the MMTV-PyMT Mouse Model of Breast Cancer
por: Velazquez, Fabiola N., et al.
Publicado: (2021)

Loss of sphingosine kinase 1 increases lung metastases in the MMTV-PyMT mouse model of breast cancer
por: Velazquez, Fabiola N., et al.
Publicado: (2021)

No Effect of NGAL/lipocalin-2 on Aggressiveness of Cancer in the MMTV-PyMT/FVB/N Mouse Model for Breast Cancer
por: Cramer, Elisabeth P., et al.
Publicado: (2012)

Anti-matrix metalloproteinase-9 DNAzyme decreases tumor growth in the MMTV-PyMT mouse model of breast cancer
por: Hallett, Miranda A, et al.
Publicado: (2013)

Mammary Tumorigenesis and Metabolome in Male Adipose Specific Monocyte Chemotactic Protein-1 Deficient MMTV-PyMT Mice Fed a High-Fat Diet
por: Yan, Lin, et al.
Publicado: (2021)

Deletion of Col15a1 Modulates the Tumour Extracellular Matrix and Leads to Increased Tumour Growth in the MMTV-PyMT Mouse Mammary Carcinoma Model
por: Martínez-Nieto, Guillermo, et al.
Publicado: (2021)

Immune Checkpoint Blockade Improves Chemotherapy in the PyMT Mammary Carcinoma Mouse Model
por: Sirait-Fischer, Evelyn, et al.
Publicado: (2020)

Chronic Stress Exposure Suppresses Mammary Tumor Growth and Reduces Circulating Exosome TGF-β Content via β-Adrenergic Receptor Signaling in MMTV-PyMT Mice
por: Dawes, Ryan P, et al.
Publicado: (2020)

Frequent overexpression of AMAP1, an Arf6 effector in cell invasion, is characteristic of the MMTV-PyMT rather than the MMTV-Neu human breast cancer model
por: Otsuka, Yutaro, et al.
Publicado: (2018)

S100A10 Has a Critical Regulatory Function in Mammary Tumor Growth and Metastasis: Insights Using MMTV-PyMT Oncomice and Clinical Patient Sample Analysis
por: Bharadwaj, Alamelu G., et al.
Publicado: (2020)

GU81, a VEGFR2 antagonist peptoid, enhances the anti-tumor activity of doxorubicin in the murine MMTV-PyMT transgenic model of breast cancer
por: Lynn, Kristi D, et al.
Publicado: (2010)

PyMT-1099, a versatile murine cell model for EMT in breast cancer
por: Saxena, Meera, et al.
Publicado: (2018)

Endogenous myoglobin expression in mouse models of mammary carcinoma reduces hypoxia and metastasis in PyMT mice
por: Aboouf, Mostafa A., et al.
Publicado: (2023)

Author Correction: PyMT-1099, a versatile murine cell model for EMT in breast cancer
por: Saxena, Meera, et al.
Publicado: (2020)

RHAMM regulates MMTV-PyMT-induced lung metastasis by connecting STING-dependent DNA damage sensing to interferon/STAT1 pro-apoptosis signaling
por: Tolg, Cornelia, et al.
Publicado: (2023)

Rank ectopic expression in the presence of Neu and PyMT oncogenes alters mammary epithelial cell populations and their tumorigenic potential
por: Cordero, Alex, et al.
Publicado: (2023)

Correction to: Rank ectopic expression in the presence of Neu and PyMT oncogenes alters mammary epithelial cell populations and their tumorigenic potential
por: Cordero, Alex, et al.
Publicado: (2023)

Collagen induced arthritis increases secondary metastasis in MMTV-PyV MT mouse model of mammary cancer
por: Roy, Lopamudra Das, et al.
Publicado: (2011)

High folic acid diet enhances tumour growth in PyMT-induced breast cancer
por: Hansen, Mariann Fagernæs, et al.
Publicado: (2017)

Ovarian cycle stage critically affects 21-gene recurrence scores in Mmtv-Pymt mouse mammary tumours
por: Bernhardt, Sarah M., et al.
Publicado: (2021)

PyMT-Maclow: A novel, inducible, murine model for determining the role of CD68 positive cells in breast tumor development
por: Rumney, Robin M. H., et al.
Publicado: (2017)

MicroRNA expression and gene regulation drive breast cancer progression and metastasis in PyMT mice
por: Nogales-Cadenas, Ruben, et al.
Publicado: (2016)

Characterization of Mammary Tumors Arising from MMTV-PyVT Transgenic Mice
por: Liu, Chien-Liang, et al.
Publicado: (2023)

Breast tumors in PyMT transgenic mice expressing mitochondrial catalase have decreased labeling for macrophages and endothelial cells
por: Fatemie, Sy, et al.
Publicado: (2012)

Cysteine cathepsin activity suppresses osteoclastogenesis of myeloid-derived suppressor cells in breast cancer
por: Edgington-Mitchell, Laura E., et al.
Publicado: (2015)

Insights from transgenic mouse models of PyMT-induced breast cancer: recapitulating human breast cancer progression in vivo
por: Attalla, Sherif, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_3uvtnsrouass04ho2iicu58c16