PNPLA3-I148M Variant Promotes the Progression of Liver Fibrosis by Inducing Mitochondrial Dysfunction

Patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 polymorphism (I148M) is strongly associated with non-alcoholic steatohepatitis and advanced fibrosis; however, the underlying mechanisms remain largely unknown. In this study, we investigated the effect of PNPLA3-I148M on the activatio...

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Detalles Bibliográficos
Autores principales: Gou, Yusong, Wang, Lifei, Zhao, Jinhan, Xu, Xiaoyi, Xu, Hangfei, Xie, Fang, Wang, Yanjun, Feng, Yingmei, Zhang, Jing, Zhang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253263/
https://www.ncbi.nlm.nih.gov/pubmed/37298640
http://dx.doi.org/10.3390/ijms24119681

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253263/
https://www.ncbi.nlm.nih.gov/pubmed/37298640
http://dx.doi.org/10.3390/ijms24119681

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