Cargando…

Empagliflozin Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Rats by Modulating Sesn2/AMPK/Nrf2 Signaling and Targeting Ferroptosis and Autophagy

Pulmonary fibrosis (PF) is a life-threatening disorder that severely disrupts normal lung architecture and function, resulting in severe respiratory failure and death. It has no definite treatment. Empagliflozin (EMPA), a sodium-glucose cotransporter 2 (SGLT2) inhibitor, has protective potential in...

Descripción completa

Detalles Bibliográficos
Autores principales:	El-Horany, Hemat El-Sayed, Atef, Marwa Mohamed, Abdel Ghafar, Muhammad Tarek, Fouda, Mohamed. H., Nasef, Nahla Anas, Hegab, Islam Ibrahim, Helal, Duaa S., Elseady, Walaa, Hafez, Yasser Mostafa, Hagag, Rasha Youssef, Seleem, Monira Abdelmoaty, Saleh, Mai Mahmoud, Radwan, Doaa A., Abd El-Lateef, Amal Ezzat, Abd-Ellatif, Rania Nagi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253289/ https://www.ncbi.nlm.nih.gov/pubmed/37298433 http://dx.doi.org/10.3390/ijms24119481

Ejemplares similares

Adrenomedullin Mitigates Doxorubicin-Induced Nephrotoxicity in Rats: Role of Oxidative Stress, Inflammation, Apoptosis, and Pyroptosis
por: Abd-Ellatif, Rania Nagi, et al.
Publicado: (2022)

Clinical application of RUBCN/SESN2 mediated inhibition of autophagy as biomarkers of diabetic kidney disease
por: Watany, Mona M., et al.
Publicado: (2022)

Targeting Oxidative Stress, Autophagy, and Apoptosis by Quercetin to Ameliorate Cisplatin-induced Peripheral Neuropathy in Rats
por: Mahmoud, Heba A., et al.
Publicado: (2023)

Prognostic Value of Brain and Acute Leukemia Cytoplasmic Gene Expression in Egyptian Children with Acute Myeloid Leukemia
por: Hagag, Adel A., et al.
Publicado: (2015)

Therapeutic Value of Combined Therapy with Deferasirox and Silymarin on Iron Overload in Children with Beta Thalassemia
por: Hagag, Adel A., et al.
Publicado: (2013)

Clinical Significance of Assessment of Thrombospondin and Placenta Growth Factor Levels in Patients with Sickle Cell Anemia: Two Centers Egyptian Studies
por: Hagag, Adel A, et al.
Publicado: (2014)

Hypoxia-induced autophagy in triple negative breast cancer: association with prognostic variables, patients’ survival and response to neoadjuvant chemotherapy
por: El-Guindy, Dina M., et al.
Publicado: (2023)

Amelioration of Cisplatin-Induced Ototoxicity in Rats by L-arginine: The Role of Nitric Oxide, Transforming Growth Factor Beta 1 and Nrf2/HO-1 Pathway
por: Estfanous, Remon S, et al.
Publicado: (2020)

Drugs with new lease of life as quorum sensing inhibitors: for combating MDR Acinetobacter baumannii infections
por: Seleem, Noura M., et al.
Publicado: (2020)

Ulinastatin ameliorated streptozotocin-induced diabetic nephropathy: Potential effects via modulating the components of gut-kidney axis and restoring mitochondrial homeostasis
por: Rizk, Fatma H., et al.
Publicado: (2023)

Coagulation Profile in COVID-19 Patients and its Relation to Disease Severity and Overall Survival: A Single-Center Study
por: Abd El-Lateef, Amal Ezzat, et al.
Publicado: (2022)

Mitochondrial localization of SESN2
por: Kovaleva, Irina E., et al.
Publicado: (2020)

Tailoring Risperidone-Loaded Glycethosomal In Situ Gels Using Box–Behnken Design for Treatment of Schizophrenia-Induced Rats via Intranasal Route
por: Abdallah, Marwa H., et al.
Publicado: (2023)

Mechanistic Insights into Ameliorating Effect of Geraniol on d-Galactose Induced Memory Impairment in Rats
por: Atef, Marwa Mohamed, et al.
Publicado: (2022)

Vitamin D as an Adjuvant Therapy in Neonatal Hypoxia: Is it Beneficial?
por: Hagag, Adel A., et al.
Publicado: (2019)

Prognostic Impact of WT-1 Gene Expression in Egyptian Children with Acute Lymphoblastic Leukemia
por: Hagag, Adel A, et al.
Publicado: (2016)

Novel Cellulose Derivatives Containing Metal (Cu, Fe, Ni) Oxide Nanoparticles as Eco-Friendly Corrosion Inhibitors for C-Steel in Acidic Chloride Solutions
por: Gouda, Mohamed, et al.
Publicado: (2021)

Case Report: Clinical manifestation and dental management of Papillon-Lefèvre syndrome
por: Yousry, Yasmin Mohamed, et al.
Publicado: (2018)

Estrogen and Progesterone Expression in Colorectal Carcinoma: A Clinicopathological Study
por: Abd ElLateef, Asmaa Abd ElGhany, et al.
Publicado: (2020)

5-Arylidene-1,3-dialkylbarbituric acid derivatives as efficient corrosion inhibitors for carbon steel in molar hydrochloric acid solution
por: Abd El-Khalek, Khaled M., et al.
Publicado: (2022)

Functional Outcome Following Proximal Tibial Osteosarcoma Resection and Reconstruction by Modular Endoprosthesis
por: Ebeid, Walid Atef, et al.
Publicado: (2022)

Empagliflozin Protects against Haloperidol Experimentally-Induced Ovarian Toxicity
por: Abdelzaher, Walaa Yehia, et al.
Publicado: (2023)

Effect of L-Ornithine application on improving drought tolerance in sugar beet plants
por: Hussein, Hebat-Allah A., et al.
Publicado: (2019)

Experimental and computational approaches of methoxy naphthylbithiophene derivatives and their use as corrosion protection for carbon steel in acidic medium
por: Fouda, Abd El-Aziz S., et al.
Publicado: (2023)

SESN2 correlates with advantageous prognosis in hepatocellular carcinoma
por: Chen, Shaosen, et al.
Publicado: (2017)

Synthesis of inventive biphenyl and azabiphenyl derivatives as potential insecticidal agents against the cotton leafworm, Spodoptera littoralis
por: Ghaith, Eslam A., et al.
Publicado: (2023)

Interference With the AMPKα/mTOR/NLRP3 Signaling and the IL-23/IL-17 Axis Effectively Protects Against the Dextran Sulfate Sodium Intoxication in Rats: A New Paradigm in Empagliflozin and Metformin Reprofiling for the Management of Ulcerative Colitis
por: Youssef, Mahmoud E., et al.
Publicado: (2021)

Anticorrosion Evaluation of Novel Water-Soluble Schiff Base Molecules for C1018 Steel in CO(2)-Saturated Brine by Computational and Experimental Methodologies
por: Abd El-Lateef, Hany M., et al.
Publicado: (2023)

To Compare and Analyze the Potency of two Topical Anesthetic Gels in Reducing Inferior Alveolar Injection Pain in Children of 8–12 Years: A Double-Blinded Clinical Trial
por: Patel, Dharati, et al.
Publicado: (2021)

Vasopressin Continuous Infusion Improves Intracranial Pressure and Patient Outcomes after Surgical Clipping or Endovascular Coiling of Cerebral Aneurysm
por: Elgebaly, Ahmed Said, et al.
Publicado: (2019)

Evaluation of Surface Properties and Elastic Modulus of CAD-CAM Milled, 3D Printed, and Compression Moulded Denture Base Resins: An In Vitro Study
por: Zeidan, Ahmed Abd El-latif, et al.
Publicado: (2022)

Condylar Fractures: Review of 40 Cases
por: Mahgoub, Mohamed Ali, et al.
Publicado: (2018)

Low Serum 25-Hydroxy Vitamin D (25-OHD) and Hepatic Encephalopathy in HCV-Related Liver Cirrhosis
por: Afifi, Mohamed Abd Ellatif, et al.
Publicado: (2021)

Cryoglobulinaemia in Egyptian Patients with Extrahepatic Cutaneous Manifestations of Chronic Hepatitis C Virus Infection
por: Hegab, Doaa Salah, et al.
Publicado: (2015)

Preparation, Characterization, and Evaluation of Macrocrystalline and Nanocrystalline Cellulose as Potential Corrosion Inhibitors for SS316 Alloy during Acid Pickling Process: Experimental and Computational Methods
por: Toghan, Arafat, et al.
Publicado: (2021)

Endoscopic assisted transoral approach with palatal splitting for a giant retropharyngeal schwannoma: a challenging case
por: El-Fattah, Ahmed Musaad Abd, et al.
Publicado: (2022)

Effect of dietary calcium and phosphorus levels on growth, carcass characteristics and liver and kidney functions of growing Egyptian geese
por: Alagawany, Mahmoud, et al.
Publicado: (2021)

Novel pyrimidine-bichalcophene derivatives as corrosion inhibitors for copper in 1 M nitric acid solution
por: Khaled, Mai A., et al.
Publicado: (2021)

Development and Optimization of Erythromycin Loaded Transethosomes Cinnamon Oil Based Emulgel for Antimicrobial Efficiency
por: Abdallah, Marwa H., et al.
Publicado: (2023)

Mechanical vestibular stimulation versus traditional balance exercises in children with Down syndrome
por: Nahla, Ibrahim M, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_bmfl4i1cibfnkbjdps5kqpt36j