Mind the Curve: Dose–Response Fitting Biases the Synergy Scores across Software Used for Chemotherapy Combination Studies

Drug combinations are increasingly studied in the field of anticancer agents. Mathematical models, such as Loewe, Bliss, and HSA, are used to interpret drug combinations, while informatics tools help cancer researchers identify the most effective combinations. However, the different algorithms each...

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Detalles Bibliográficos
Autores principales: Fuentealba-Manosalva, Olga, Mansilla, Matías, Buelvas, Neudo, Martin-Martin, Antonia, Torres, Cristian G., López-Muñoz, Rodrigo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253300/
https://www.ncbi.nlm.nih.gov/pubmed/37298656
http://dx.doi.org/10.3390/ijms24119705

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253300/
https://www.ncbi.nlm.nih.gov/pubmed/37298656
http://dx.doi.org/10.3390/ijms24119705

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