Smooth Muscle-Alpha Actin R149C Pathogenic Variant Downregulates Integrin Recruitment at Cell-Matrix Adhesions and Decreases Cellular Contractility

Thoracic aortic aneurysm is found in patients with ACTA2 pathogenic variants. ACTA2 missense variants are associated with impaired aortic smooth muscle cell (SMC) contraction. This study tested the hypothesis that the Acta2(R149C/+) variant alters actin isoform expression and decreases integrin recr...

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Detalles Bibliográficos
Autores principales: Ojha, Krishna R., Kim, Hyoseon, Padgham, Samuel, Hopkins, Laura, Zamen, Robert J., Chattopadhyay, Abhijnan, Han, Gang, Milewicz, Dianna M., Massett, Michael P., Trache, Andreea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253315/
https://www.ncbi.nlm.nih.gov/pubmed/37298565
http://dx.doi.org/10.3390/ijms24119616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253315/
https://www.ncbi.nlm.nih.gov/pubmed/37298565
http://dx.doi.org/10.3390/ijms24119616

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