Nuclear Translocation of LDHA Promotes the Catabolism of BCAAs to Sustain GBM Cell Proliferation through the TxN Antioxidant Pathway

Glutamate is excitotoxic to neurons. The entry of glutamine or glutamate from the blood into the brain is limited. To overcome this, branched-chain amino acids (BCAAs) catabolism replenishes the glutamate in brain cells. Branched-chain amino acid transaminase 1 (BCAT1) activity is silenced by epigen...

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Detalles Bibliográficos
Autores principales: Li, Zhujun, Gu, Zhiyan, Wang, Lan, Guan, Yun, Lyu, Yingying, Zhang, Jialong, Wang, Yin, Wang, Xin, Xiong, Ji, Liu, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253380/
https://www.ncbi.nlm.nih.gov/pubmed/37298317
http://dx.doi.org/10.3390/ijms24119365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253380/
https://www.ncbi.nlm.nih.gov/pubmed/37298317
http://dx.doi.org/10.3390/ijms24119365

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