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Nuclear Translocation of LDHA Promotes the Catabolism of BCAAs to Sustain GBM Cell Proliferation through the TxN Antioxidant Pathway
Glutamate is excitotoxic to neurons. The entry of glutamine or glutamate from the blood into the brain is limited. To overcome this, branched-chain amino acids (BCAAs) catabolism replenishes the glutamate in brain cells. Branched-chain amino acid transaminase 1 (BCAT1) activity is silenced by epigen...
Autores principales: | Li, Zhujun, Gu, Zhiyan, Wang, Lan, Guan, Yun, Lyu, Yingying, Zhang, Jialong, Wang, Yin, Wang, Xin, Xiong, Ji, Liu, Ying |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253380/ https://www.ncbi.nlm.nih.gov/pubmed/37298317 http://dx.doi.org/10.3390/ijms24119365 |
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