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Calpain-3 Is Not a Sodium Dependent Protease and Simply Requires Calcium for Activation

Calpain-3 (CAPN3) is a muscle-specific member of the calpain family of Ca(2+)-dependent proteases. It has been reported that CAPN3 can also be autolytically activated by Na(+) ions in the absence of Ca(2+), although this was only shown under non-physiological ionic conditions. Here we confirm that C...

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Detalles Bibliográficos
Autores principales: Wette, Stefan G., Lamb, Graham D., Murphy, Robyn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253552/
https://www.ncbi.nlm.nih.gov/pubmed/37298357
http://dx.doi.org/10.3390/ijms24119405