A dePEGylated Lipopeptide-Based Pan-Coronavirus Fusion Inhibitor Exhibits Potent and Broad-Spectrum Anti-HIV-1 Activity without Eliciting Anti-PEG Antibodies

We previously identified a lipopeptide, EK1C4, by linking cholesterol to EK1, a pan-CoV fusion inhibitory peptide via a polyethylene glycol (PEG) linker, which showed potent pan-CoV fusion inhibitory activity. However, PEG can elicit antibodies to PEG in vivo, which will attenuate its antiviral acti...

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Detalles Bibliográficos
Autores principales: Xu, Ling, Wang, Chao, Xu, Wei, Xing, Lixiao, Zhou, Jie, Pu, Jing, Fu, Mingming, Lu, Lu, Jiang, Shibo, Wang, Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253554/
https://www.ncbi.nlm.nih.gov/pubmed/37298729
http://dx.doi.org/10.3390/ijms24119779

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253554/
https://www.ncbi.nlm.nih.gov/pubmed/37298729
http://dx.doi.org/10.3390/ijms24119779

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