A Non-Systemic Phosphodiesterase-5 Inhibitor Suppresses Colon Proliferation in Mice

Phosphodiesterase-5 inhibitors (PDE5i) are under investigation for repurposing for colon cancer prevention. A drawback to conventional PDE5i are their side-effects and drug–drug interactions. We designed an analog of the prototypical PDE5i sildenafil by replacing the methyl group on the piperazine r...

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Detalles Bibliográficos
Autores principales: Lee, Avelina, Lebedyeva, Iryna, Zhi, Wenbo, Senthil, Vani, Cheema, Herjot, Brands, Michael W., Bush, Weston, Lambert, Nevin A., Snipes, Madeline, Browning, Darren D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253591/
https://www.ncbi.nlm.nih.gov/pubmed/37298349
http://dx.doi.org/10.3390/ijms24119397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253591/
https://www.ncbi.nlm.nih.gov/pubmed/37298349
http://dx.doi.org/10.3390/ijms24119397

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