Enhancing the Catalytic Activity of Thermo-Asparaginase from Thermococcus sibiricus by a Double Mesophilic-like Mutation in the Substrate-Binding Region

L-asparaginases (L-ASNases) of microbial origin are the mainstay of blood cancer treatment. Numerous attempts have been performed for genetic improvement of the main properties of these enzymes. The substrate-binding Ser residue is highly conserved in L-ASNases regardless of their origin or type. Ho...

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Detalles Bibliográficos
Autores principales: Dumina, Maria, Zhdanov, Dmitry, Zhgun, Alexander, Pokrovskaya, Marina, Aleksandrova, Svetlana, Veselovsky, Alexander, El’darov, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253665/
https://www.ncbi.nlm.nih.gov/pubmed/37298582
http://dx.doi.org/10.3390/ijms24119632

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253665/
https://www.ncbi.nlm.nih.gov/pubmed/37298582
http://dx.doi.org/10.3390/ijms24119632

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