Methotrexate Provokes Disparate Folate Metabolism Gene Expression and Alternative Splicing in Ex Vivo Monocytes and GM-CSF- and M-CSF-Polarized Macrophages

Macrophages constitute important immune cell targets of the antifolate methotrexate (MTX) in autoimmune diseases, including rheumatoid arthritis. Regulation of folate/MTX metabolism remains poorly understood upon pro-inflammatory (M1-type/GM-CSF-polarized) and anti-inflammatory (M2-type/M-CSF-polari...

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Detalles Bibliográficos
Autores principales: Muller, Ittai B., Lin, Marry, de Jonge, Robert, Will, Nico, López-Navarro, Baltasar, van der Laken, Conny, Struys, Eduard A., Oudejans, Cees B. M., Assaraf, Yehuda G., Cloos, Jacqueline, Puig-Kröger, Amaya, Jansen, Gerrit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253671/
https://www.ncbi.nlm.nih.gov/pubmed/37298590
http://dx.doi.org/10.3390/ijms24119641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253671/
https://www.ncbi.nlm.nih.gov/pubmed/37298590
http://dx.doi.org/10.3390/ijms24119641

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