IGFBP7 Fuels the Glycolytic Metabolism in B-Cell Precursor Acute Lymphoblastic Leukemia by Sustaining Activation of the IGF1R–Akt–GLUT1 Axis

Increased glycolytic metabolism plays an important role in B-cell precursor Acute Lymphoblastic Leukemia (BCP-ALL). We previously showed that IGFBP7 exerts mitogenic and prosuvival effects in ALL by promoting IGF1 receptor (IGF1R) permanence on the cell surface, thus prolonging Akt activation upon I...

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Detalles Bibliográficos
Autores principales: Artico, Leonardo Luís, Ruas, Juliana Silveira, Teixeira Júnior, José Ricardo, Migita, Natacha Azussa, Seguchi, Gustavo, Shi, Xinghua, Brandalise, Silvia Regina, Castilho, Roger Frigério, Yunes, José Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253689/
https://www.ncbi.nlm.nih.gov/pubmed/37298628
http://dx.doi.org/10.3390/ijms24119679

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253689/
https://www.ncbi.nlm.nih.gov/pubmed/37298628
http://dx.doi.org/10.3390/ijms24119679

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