Virtual Screening Combined with Enzymatic Assays to Guide the Discovery of Novel SIRT2 Inhibitors

Sirtuin isoform 2 (SIRT2) is one of the seven sirtuin isoforms present in humans, being classified as class III histone deacetylases (HDACs). Based on the high sequence similarity among SIRTs, the identification of isoform selective modulators represents a challenging task, especially for the high c...

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Detalles Bibliográficos
Autores principales: Scarano, Naomi, Abbotto, Elena, Musumeci, Francesca, Salis, Annalisa, Brullo, Chiara, Fossa, Paola, Schenone, Silvia, Bruzzone, Santina, Cichero, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253774/
https://www.ncbi.nlm.nih.gov/pubmed/37298312
http://dx.doi.org/10.3390/ijms24119363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253774/
https://www.ncbi.nlm.nih.gov/pubmed/37298312
http://dx.doi.org/10.3390/ijms24119363

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