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Virtual Screening Combined with Enzymatic Assays to Guide the Discovery of Novel SIRT2 Inhibitors
Sirtuin isoform 2 (SIRT2) is one of the seven sirtuin isoforms present in humans, being classified as class III histone deacetylases (HDACs). Based on the high sequence similarity among SIRTs, the identification of isoform selective modulators represents a challenging task, especially for the high c...
Autores principales: | Scarano, Naomi, Abbotto, Elena, Musumeci, Francesca, Salis, Annalisa, Brullo, Chiara, Fossa, Paola, Schenone, Silvia, Bruzzone, Santina, Cichero, Elena |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253774/ https://www.ncbi.nlm.nih.gov/pubmed/37298312 http://dx.doi.org/10.3390/ijms24119363 |
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