Molecular Dynamic Simulations Reveal the Activation Mechanisms of Oxidation-Induced TRPV1

Transient receptor potential vanilloid 1 (TRPV1), a non-selective cation channel, can be directly activated by oxidants through cysteine modification. However, the patterns of cysteine modification are unclear. Structural analysis showed that the free sulfhydryl groups of residue pairs C387 and C391...

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Detalles Bibliográficos
Autores principales: Chu, Yanyan, Zhang, Huanhuan, Yang, Mengke, Yu, Rilei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253787/
https://www.ncbi.nlm.nih.gov/pubmed/37298504
http://dx.doi.org/10.3390/ijms24119553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253787/
https://www.ncbi.nlm.nih.gov/pubmed/37298504
http://dx.doi.org/10.3390/ijms24119553

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