Can Allostery Be a Key Strategy for Targeting PTP1B in Drug Discovery? A Lesson from Trodusquemine

Protein tyrosine phosphatase 1B (PTP1B) is an enzyme crucially implicated in aberrations of various signaling pathways that underlie the development of different human pathologies, such as obesity, diabetes, cancer, and neurodegenerative disorders. Its inhibition can prevent these pathogenetic event...

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Detalles Bibliográficos
Autores principales: Maccari, Rosanna, Ottanà, Rosaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253921/
https://www.ncbi.nlm.nih.gov/pubmed/37298571
http://dx.doi.org/10.3390/ijms24119621

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253921/
https://www.ncbi.nlm.nih.gov/pubmed/37298571
http://dx.doi.org/10.3390/ijms24119621

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