Small Molecule c-KIT Inhibitors for the Treatment of Gastrointestinal Stromal Tumors: A Review on Synthesis, Design Strategies, and Structure–Activity Relationship (SAR)

The proto-oncogenic protein, c-KIT, plays a crucial role in regulating cellular transformation and differentiation processes, such as proliferation, survival, adhesion, and chemotaxis. The overexpression of, and mutations, in c-KIT can lead to its dysregulation and promote various human cancers, par...

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Detalles Bibliográficos
Autores principales: Godesi, Sreenivasulu, Lee, Joohan, Nada, Hossam, Quan, Guofeng, Elkamhawy, Ahmed, Choi, Yongseok, Lee, Kyeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253927/
https://www.ncbi.nlm.nih.gov/pubmed/37298401
http://dx.doi.org/10.3390/ijms24119450

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253927/
https://www.ncbi.nlm.nih.gov/pubmed/37298401
http://dx.doi.org/10.3390/ijms24119450

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