Early Molecular Insights into Thanatin Analogues Binding to A. baumannii LptA

The cationic antimicrobial ß-hairpin, thanatin, was recently developed into drug-like analogues active against carbapenem-resistant Enterobacteriaceae (CRE). The analogues represent new antibiotics with a novel mode of action targeting LptA in the periplasm and disrupting LPS transport. The compound...

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Detalles Bibliográficos
Autores principales: Oi, Kathryn K., Moehle, Kerstin, Schuster, Matthias, Zerbe, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254193/
https://www.ncbi.nlm.nih.gov/pubmed/37298811
http://dx.doi.org/10.3390/molecules28114335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254193/
https://www.ncbi.nlm.nih.gov/pubmed/37298811
http://dx.doi.org/10.3390/molecules28114335

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