Design, Synthesis and Biological Evaluation of α-Synuclein Proteolysis-Targeting Chimeras

α-Synuclein aggregation under pathological conditions is one of the causes of related neurodegenerative diseases. PROTACs (proteolysis targeting chimeras) are bifunctional small molecules that induce a post-translational erasure of proteins via the ubiquitination of target proteins by E3 ubiquitin l...

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Detalles Bibliográficos
Autores principales: Wen, Tianzhi, Chen, Jian, Zhang, Wenqian, Pang, Jiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254247/
https://www.ncbi.nlm.nih.gov/pubmed/37298935
http://dx.doi.org/10.3390/molecules28114458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254247/
https://www.ncbi.nlm.nih.gov/pubmed/37298935
http://dx.doi.org/10.3390/molecules28114458

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