Substituents Regulate the Cyclization of Conjugated Alkynes to Accurately Construct Cyclo-(E)-[3]dendralenes

Substituent-regulated cyclization of conjugated alkynes with acid catalysis was developed in this paper, and it provides a straightforward synthesis of cyclic-(E)-[3]dendralenes. Depending on the electronic effect of the aromatic ring pairing, a variety of phosphinyl quintuplet/hexa cyclo-[3]dendral...

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Autores principales: Xia, Yun-Tao, Li, Ya-Xin, Bi, Tong-Tong, Lian, Wei, Wang, Xia, Yan, Meng, Guo, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254459/
https://www.ncbi.nlm.nih.gov/pubmed/37298858
http://dx.doi.org/10.3390/molecules28114382
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author Xia, Yun-Tao
Li, Ya-Xin
Bi, Tong-Tong
Lian, Wei
Wang, Xia
Yan, Meng
Guo, Tao
author_facet Xia, Yun-Tao
Li, Ya-Xin
Bi, Tong-Tong
Lian, Wei
Wang, Xia
Yan, Meng
Guo, Tao
author_sort Xia, Yun-Tao
collection PubMed
description Substituent-regulated cyclization of conjugated alkynes with acid catalysis was developed in this paper, and it provides a straightforward synthesis of cyclic-(E)-[3]dendralenes. Depending on the electronic effect of the aromatic ring pairing, a variety of phosphinyl quintuplet/hexa cyclo-[3]dendralenes with diverse substitution patterns are accessible, with good efficiency and high stereoselectivity. This self-cyclization process achieves the first precise construction of a phosphinylcyclo-(E)-[3]dendralene from conjugated alkynes to aromatization.
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spelling pubmed-102544592023-06-10 Substituents Regulate the Cyclization of Conjugated Alkynes to Accurately Construct Cyclo-(E)-[3]dendralenes Xia, Yun-Tao Li, Ya-Xin Bi, Tong-Tong Lian, Wei Wang, Xia Yan, Meng Guo, Tao Molecules Article Substituent-regulated cyclization of conjugated alkynes with acid catalysis was developed in this paper, and it provides a straightforward synthesis of cyclic-(E)-[3]dendralenes. Depending on the electronic effect of the aromatic ring pairing, a variety of phosphinyl quintuplet/hexa cyclo-[3]dendralenes with diverse substitution patterns are accessible, with good efficiency and high stereoselectivity. This self-cyclization process achieves the first precise construction of a phosphinylcyclo-(E)-[3]dendralene from conjugated alkynes to aromatization. MDPI 2023-05-27 /pmc/articles/PMC10254459/ /pubmed/37298858 http://dx.doi.org/10.3390/molecules28114382 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xia, Yun-Tao
Li, Ya-Xin
Bi, Tong-Tong
Lian, Wei
Wang, Xia
Yan, Meng
Guo, Tao
Substituents Regulate the Cyclization of Conjugated Alkynes to Accurately Construct Cyclo-(E)-[3]dendralenes
title Substituents Regulate the Cyclization of Conjugated Alkynes to Accurately Construct Cyclo-(E)-[3]dendralenes
title_full Substituents Regulate the Cyclization of Conjugated Alkynes to Accurately Construct Cyclo-(E)-[3]dendralenes
title_fullStr Substituents Regulate the Cyclization of Conjugated Alkynes to Accurately Construct Cyclo-(E)-[3]dendralenes
title_full_unstemmed Substituents Regulate the Cyclization of Conjugated Alkynes to Accurately Construct Cyclo-(E)-[3]dendralenes
title_short Substituents Regulate the Cyclization of Conjugated Alkynes to Accurately Construct Cyclo-(E)-[3]dendralenes
title_sort substituents regulate the cyclization of conjugated alkynes to accurately construct cyclo-(e)-[3]dendralenes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254459/
https://www.ncbi.nlm.nih.gov/pubmed/37298858
http://dx.doi.org/10.3390/molecules28114382
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