The Effects of 1-O-Acetylbritannilactone Isolated from Inula britannica Flowers on Human Neutrophil Elastase and Inflammation of RAW 264.7 Cells and Zebrafish Larvae

During a search for natural inflammatory inhibitors, 1-O-acetylbritannilactone (ABL), a sesquiterpene lactone, was isolated from the flowers of Inula britannica. ABL significantly inhibited human neutrophil elastase (HNE) with a half-maximal inhibitory concentration (IC(50)) of 3.2 ± 0.3 µM, thus di...

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Detalles Bibliográficos
Autores principales: Lee, Ik Soo, Lee, Yu-Ri, Sim, Jea Heon, Kim, Ki Mo, Kim, Young Sook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254531/
https://www.ncbi.nlm.nih.gov/pubmed/37298794
http://dx.doi.org/10.3390/molecules28114320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254531/
https://www.ncbi.nlm.nih.gov/pubmed/37298794
http://dx.doi.org/10.3390/molecules28114320

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