Intralesional administration of VAX014 facilitates in situ immunization and potentiates immune checkpoint blockade in immunologically cold tumors

BACKGROUND: Immunologically cold tumors with an ‘immune desert’ phenotype lack tumor-infiltrating lymphocytes (TILs) and are typically impervious to systemic immune checkpoint blockade (ICB). Intratumoral treatment of tumors with immunomodulatory agents can promote local tumor inflammation leading t...

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Detalles Bibliográficos
Autores principales: Reil, Katherine A, Tsuji, Shingo, Molina, Elsa, Nelson, Kinsey L, McGuire, Kathleen L, Giacalone, Matthew J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Oncolytic and Local Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254596/
https://www.ncbi.nlm.nih.gov/pubmed/37290924
http://dx.doi.org/10.1136/jitc-2023-006749

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254596/
https://www.ncbi.nlm.nih.gov/pubmed/37290924
http://dx.doi.org/10.1136/jitc-2023-006749

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