Rational Engineering of (S)-Norcoclaurine Synthase for Efficient Benzylisoquinoline Alkaloids Biosynthesis

(S)-Norcoclaurine is synthesized in vivo through a metabolic pathway that ends with (S)-norcoclaurine synthase (NCS). The former constitutes the scaffold for the biosynthesis of all benzylisoquinoline alkaloids (BIAs), including many drugs such as the opiates morphine and codeine and the semi-synthe...

Descripción completa

Detalles Bibliográficos
Autores principales: De Sousa, João P. M., Oliveira, Nuno C. S. A., Fernandes, Pedro A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254637/
https://www.ncbi.nlm.nih.gov/pubmed/37298742
http://dx.doi.org/10.3390/molecules28114265

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254637/
https://www.ncbi.nlm.nih.gov/pubmed/37298742
http://dx.doi.org/10.3390/molecules28114265

Ejemplares similares