Desymmetrization of Prochiral N-Pyrazolyl Maleimides via Organocatalyzed Asymmetric Michael Addition with Pyrazolones: Construction of Tri-N-Heterocyclic Scaffolds Bearing Both Central and Axial Chirality

The desymmetrization of N-pyrazolyl maleimides was realized through an asymmetric Michael addition by using pyrazolones under mild conditions, leading to the formation of a tri-N-heterocyclic pyrazole–succinimide–pyrazolone assembly in high yields with excellent enantioselectivities (up to 99% yield...

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Detalles Bibliográficos
Autores principales: Geng, Jianqi, Wei, Xingfu, He, Biru, Hao, Yuting, Qu, Jingping, Wang, Baomin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254726/
https://www.ncbi.nlm.nih.gov/pubmed/37298754
http://dx.doi.org/10.3390/molecules28114279

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254726/
https://www.ncbi.nlm.nih.gov/pubmed/37298754
http://dx.doi.org/10.3390/molecules28114279

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