Development and Validation of a New LC-MS/MS Bioanalytical Method for the Simultaneous Determination of Levodopa, Levodopa Methyl Ester, and Carbidopa in Human Plasma Samples

Levodopa (L-DOPA) treatment, combined with the administration of dopa-decarboxylase inhibitors (DDCIs), is still the most effective symptomatic treatment of Parkinson’s disease (PD). Although its efficacy in the early stage of the disease has been confirmed, its complex pharmacokinetics (PK) increas...

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Detalles Bibliográficos
Autores principales: Molteni, Linda, Charlier, Bruno, Izzo, Viviana, Coglianese, Albino, Conti, Valeria, Eleopra, Roberto, Cilia, Roberto, Capelli, Chiara, D’Urso, Annachiara, de Grazia, Ugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254897/
https://www.ncbi.nlm.nih.gov/pubmed/37298741
http://dx.doi.org/10.3390/molecules28114264

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254897/
https://www.ncbi.nlm.nih.gov/pubmed/37298741
http://dx.doi.org/10.3390/molecules28114264

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