Targeting Transcriptional CDKs 7, 8, and 9 with Anilinopyrimidine Derivatives as Anticancer Agents: Design, Synthesis, Biological Evaluation and In Silico Studies

Cyclin-dependent kinases (CDKs) are promising targets in chemotherapy. In this study, we report a series of 2-anilinopyrimidine derivatives with CDK inhibitory activity. Twenty-one compounds were synthesized and their CDK inhibitory and cytotoxic activities were evaluated. The representative compoun...

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Detalles Bibliográficos
Autores principales: Eskandrani, Razan, Al-Rasheed, Lamees S., Ansari, Siddique Akber, Bakheit, Ahmed H., Almehizia, Abdulrahman A., Almutairi, Maha, Alkahtani, Hamad M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254914/
https://www.ncbi.nlm.nih.gov/pubmed/37298748
http://dx.doi.org/10.3390/molecules28114271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10254914/
https://www.ncbi.nlm.nih.gov/pubmed/37298748
http://dx.doi.org/10.3390/molecules28114271

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