Cargando…

Neural network and kinetic modelling of human genome replication reveal replication origin locations and strengths

In human and other metazoans, the determinants of replication origin location and strength are still elusive. Origins are licensed in G1 phase and fired in S phase of the cell cycle, respectively. It is debated which of these two temporally separate steps determines origin efficiency. Experiments ca...

Descripción completa

Detalles Bibliográficos
Autores principales: Arbona, Jean-Michel, Kabalane, Hadi, Barbier, Jeremy, Goldar, Arach, Hyrien, Olivier, Audit, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256156/
https://www.ncbi.nlm.nih.gov/pubmed/37253070
http://dx.doi.org/10.1371/journal.pcbi.1011138