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Neural network and kinetic modelling of human genome replication reveal replication origin locations and strengths
In human and other metazoans, the determinants of replication origin location and strength are still elusive. Origins are licensed in G1 phase and fired in S phase of the cell cycle, respectively. It is debated which of these two temporally separate steps determines origin efficiency. Experiments ca...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256156/ https://www.ncbi.nlm.nih.gov/pubmed/37253070 http://dx.doi.org/10.1371/journal.pcbi.1011138 |