Cargando…

Acyl ghrelin improves cardiac function in heart failure and increases fractional shortening in cardiomyocytes without calcium mobilization

BACKGROUND AND AIMS: Ghrelin is an endogenous appetite-stimulating peptide hormone with potential cardiovascular benefits. Effects of acylated (activated) ghrelin were assessed in patients with heart failure and reduced ejection fraction (HFrEF) and in ex vivo mouse cardiomyocytes. METHODS AND RESUL...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lund, Lars H, Hage, Camilla, Pironti, Gianluigi, Thorvaldsen, Tonje, Ljung-Faxén, Ulrika, Zabarovskaja, Stanislava, Shahgaldi, Kambiz, Webb, Dominic-Luc, Hellström, Per M, Andersson, Daniel C, Ståhlberg, Marcus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Clinical Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256198/ https://www.ncbi.nlm.nih.gov/pubmed/36916707 http://dx.doi.org/10.1093/eurheartj/ehad100

Ejemplares similares

Ghrelin O-Acyl Transferase: Bridging Ghrelin and Energy Homeostasis
por: Shlimun, Andrew, et al.
Publicado: (2011)

Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT
por: Baldanzi, Gianluca, et al.
Publicado: (2002)

Prospective Evaluation of Ghrelin and Des-Acyl Ghrelin Plasma Levels in Children with Newly Diagnosed Epilepsy: Evidence for Reduced Ghrelin-to-Des-Acyl Ghrelin Ratio in Generalized Epilepsies
por: Costa, Anna-Maria, et al.
Publicado: (2022)

Antifibrotic Activity of Acylated and Unacylated Ghrelin
por: Angelino, Elia, et al.
Publicado: (2015)

Ghrelin, Des-Acyl Ghrelin, and Obestatin: Regulatory Roles on the Gastrointestinal Motility
por: Fujimiya, Mineko, et al.
Publicado: (2010)

β-Oxidation in ghrelin-producing cells is important for ghrelin acyl-modification
por: Ikenoya, Chika, et al.
Publicado: (2018)

Both Acyl and Des-Acyl Ghrelin Regulate Adiposity and Glucose Metabolism via Central Nervous System Ghrelin Receptors
por: Heppner, Kristy M., et al.
Publicado: (2014)

Ghrelin Receptor Influence on Cocaine Reward is Not Directly Dependent on Peripheral Acyl-Ghrelin
por: Wenthur, Cody J., et al.
Publicado: (2019)

Acylated Ghrelin and The Regulation of Lipid Metabolism in The Intestine
por: Auclair, N., et al.
Publicado: (2019)

Acylated but not des‐acyl ghrelin is neuroprotective in an MPTP mouse model of Parkinson's disease
por: Bayliss, Jacqueline A., et al.
Publicado: (2016)

Focusing on Referral Rather than Selection for Advanced Heart Failure Therapies
por: Thorvaldsen, Tonje, et al.
Publicado: (2019)

Plasma levels of acylated ghrelin in patients with insulinoma and expression of ghrelin and its receptor in insulinomas
por: Wu, Hai-Yan, et al.
Publicado: (2020)

Ghrelin octanoylation by ghrelin O-acyltransferase: protein acylation impacting metabolic and neuroendocrine signalling
por: Davis, Tasha R., et al.
Publicado: (2021)

Cardiogenic shock triggered by phaeochromocytoma crisis after an oral glucose tolerance test: a case report
por: Shahim, Bahira, et al.
Publicado: (2019)

Left atrial reservoir strain improves diagnostic accuracy of the 2016 ASE/EACVI diastolic algorithm in patients with preserved left ventricular ejection fraction: insights from the KARUM haemodynamic database( )
por: Venkateshvaran, Ashwin, et al.
Publicado: (2022)

The role of acylated ghrelin and unacylated ghrelin in the blood and hypothalamus and their interaction with nonalcoholic fatty liver disease
por: Liu, Xia, et al.
Publicado: (2020)

Use of evidence‐based therapy in heart failure with reduced ejection fraction across age strata
por: Stolfo, Davide, et al.
Publicado: (2022)

Congestion and Diuretic Resistance in Acute or Worsening Heart Failure
por: Kristjánsdóttir, Ingibjörg, et al.
Publicado: (2020)

Determination of Ghrelin Structure in the Barfin Flounder (Verasper moseri) and Involvement of Ingested Fatty Acids in Ghrelin Acylation
por: Kaiya, Hiroyuki, et al.
Publicado: (2013)

Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor
por: Wang, Yue, et al.
Publicado: (2021)

Acylation, a Conductor of Ghrelin Function in Brain Health and Disease
por: Thomas, Alanna S., et al.
Publicado: (2022)

Rivastigmine Improves Appetite by Increasing the Plasma Acyl/Des-Acyl Ghrelin Ratio and Cortisol in Alzheimer Disease
por: Furiya, Yoshiko, et al.
Publicado: (2018)

Circulating acyl and des-acyl ghrelin levels in obese adults: a systematic review and meta-analysis
por: Wang, Yanmei, et al.
Publicado: (2022)

Mechanistic and Therapeutic Implications of Extracellular Vesicles as a Potential Link Between Covid-19 and Cardiovascular Disease Manifestations
por: Pironti, Gianluigi, et al.
Publicado: (2021)

The Acute Effects of Swimming on Appetite, Food Intake, and Plasma Acylated Ghrelin
por: King, James A., et al.
Publicado: (2011)

Serum Acylated Ghrelin Is Negatively Correlated with the Insulin Resistance In the CODING study
por: Amini, Peyvand, et al.
Publicado: (2012)

Acyl Ghrelin Improves Synapse Recovery in an In Vitro Model of Postanoxic Encephalopathy
por: Stoyanova, Irina I., et al.
Publicado: (2015)

Acylated Ghrelin Supports the Ovarian Transcriptome and Follicles in the Mouse: Implications for Fertility
por: Sominsky, Luba, et al.
Publicado: (2019)

Acylated Ghrelin as a Multi-Targeted Therapy for Alzheimer's and Parkinson's Disease
por: Reich, Niklas, et al.
Publicado: (2020)

Altered acylated ghrelin response to food intake in congenital generalized lipodystrophy
por: Araújo, Camilla O. D., et al.
Publicado: (2021)

Preliminary evidence of acylated ghrelin association with depression severity in postmenopausal women
por: Naufel, Maria Fernanda, et al.
Publicado: (2021)

Antiepileptic Drugs Impair Shortening of Isolated Cardiomyocytes
por: Hulbert, Johanna, et al.
Publicado: (2017)

Unacylated ghrelin promotes adipogenesis in rodent bone marrow via ghrelin O-acyl transferase and GHS-R(1a) activity: evidence for target cell-induced acylation
por: Hopkins, Anna L., et al.
Publicado: (2017)

Engineering acyl carrier protein to enhance production of shortened fatty acids
por: Liu, Xueliang, et al.
Publicado: (2016)

Dietary Caprylic Acid (C8:0) Does Not Increase Plasma Acylated Ghrelin but Decreases Plasma Unacylated Ghrelin in the Rat
por: Lemarié, Fanny, et al.
Publicado: (2015)

Interaction between acyl-ghrelin and BMI predicts clinical outcomes in hemodialysis patients
por: Beberashvili, Ilia, et al.
Publicado: (2017)

Effects of Des-acyl Ghrelin on Insulin Sensitivity and Macrophage Polarization in Adipose Tissue
por: Yuan, Fang, et al.
Publicado: (2021)

Regional differences and coronary microvascular dysfunction in heart failure with preserved ejection fraction
por: Erhardsson, Mikael, et al.
Publicado: (2023)

Fasting and postprandial acyl and desacyl ghrelin and the acyl/desacyl ratio in obese patients before and after different types of bariatric surgery
por: Dardzińska, Jolanta A., et al.
Publicado: (2018)

Elevated ratio of acylated to unacylated ghrelin in children and young adults with Prader–Willi syndrome
por: Kuppens, R. J., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_d2aon2v4tdkiob82huk96hanj4