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Mutation rate, selection, and epistasis inferred from RNA virus haplotypes via neural posterior estimation

RNA viruses are particularly notorious for their high levels of genetic diversity, which is generated through the forces of mutation and natural selection. However, disentangling these two forces is a considerable challenge, and this may lead to widely divergent estimates of viral mutation rates, as...

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Detalles Bibliográficos
Autores principales: Caspi, Itamar, Meir, Moran, Ben Nun, Nadav, Abu Rass, Reem, Yakhini, Uri, Stern, Adi, Ram, Yoav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256221/
https://www.ncbi.nlm.nih.gov/pubmed/37305706
http://dx.doi.org/10.1093/ve/vead033