mTOR inhibition suppresses Myc-driven polyposis by inducing immunogenic cell death

Myc is a key driver of colorectal cancer initiation and progression, but remains a difficult drug target. In this study, we show that mTOR inhibition potently suppresses intestinal polyp formation, regresses established polyps, and prolongs lifespan of APC(Min/+) mice. Everolimus in diet strongly re...

Descripción completa

Detalles Bibliográficos
Autores principales: Leibowitz, Brian J., Zhao, Guangyi, Xia, Wenxin, Wang, Yuhan, Ruan, Hang, Zhang, Lin, Yu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256613/
https://www.ncbi.nlm.nih.gov/pubmed/37138032
http://dx.doi.org/10.1038/s41388-023-02706-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256613/
https://www.ncbi.nlm.nih.gov/pubmed/37138032
http://dx.doi.org/10.1038/s41388-023-02706-6

Ejemplares similares