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mTOR inhibition suppresses Myc-driven polyposis by inducing immunogenic cell death
Myc is a key driver of colorectal cancer initiation and progression, but remains a difficult drug target. In this study, we show that mTOR inhibition potently suppresses intestinal polyp formation, regresses established polyps, and prolongs lifespan of APC(Min/+) mice. Everolimus in diet strongly re...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256613/ https://www.ncbi.nlm.nih.gov/pubmed/37138032 http://dx.doi.org/10.1038/s41388-023-02706-6 |