G × E interactions as a basis for toxicological uncertainty

To transfer toxicological findings from model systems, e.g. animals, to humans, standardized safety factors are applied to account for intra-species and inter-species variabilities. An alternative approach would be to measure and model the actual compound-specific uncertainties. This biological conc...

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Detalles Bibliográficos
Autores principales: Suciu, Ilinca, Pamies, David, Peruzzo, Roberta, Wirtz, Petra H., Smirnova, Lena, Pallocca, Giorgia, Hauck, Christof, Cronin, Mark T. D., Hengstler, Jan G., Brunner, Thomas, Hartung, Thomas, Amelio, Ivano, Leist, Marcel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Guest Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256652/
https://www.ncbi.nlm.nih.gov/pubmed/37258688
http://dx.doi.org/10.1007/s00204-023-03500-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256652/
https://www.ncbi.nlm.nih.gov/pubmed/37258688
http://dx.doi.org/10.1007/s00204-023-03500-9

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