Cargando…

GLP‑1 receptor agonist protects palmitate-induced insulin resistance in skeletal muscle cells by up-regulating sestrin2 to promote autophagy

In this study, we aimed to determine whether liraglutide could effectively reduce insulin resistance (IR) by regulating Sestrin2 (SESN2) expression in L6 rat skeletal muscle cells by examining its interactions with SESN2, autophagy, and IR. L6 cells were incubated with liraglutide (10–1000 nM) in th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tian, Xue, Gao, Yu, Kong, Mowei, Zhao, Lihua, Xing, Enhong, Sun, Qitian, He, Jianqiu, Lu, Yanan, Feng, Zengbin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256699/ https://www.ncbi.nlm.nih.gov/pubmed/37296162 http://dx.doi.org/10.1038/s41598-023-36602-6

Ejemplares similares

The association between serum Sestrin2 and the risk of coronary heart disease in patients with type 2 diabetes mellitus
por: Tian, Xue, et al.
Publicado: (2022)

Mechanism of GLP-1 Receptor Agonists-Mediated Attenuation of Palmitic Acid-Induced Lipotoxicity in L6 Myoblasts
por: Kong, Mo-wei, et al.
Publicado: (2022)

Basal Insulin Use With GLP-1 Receptor Agonists
por: Anderson, Sarah L., et al.
Publicado: (2016)

Sestrin 1 ameliorates cardiac hypertrophy via autophagy activation
por: Xue, Ruicong, et al.
Publicado: (2017)

Sestrins at the Interface of ROS Control and Autophagy Regulation in Health and Disease
por: Cordani, Marco, et al.
Publicado: (2019)

Sestrins as a Therapeutic Bridge between ROS and Autophagy in Cancer
por: Sánchez-Álvarez, Miguel, et al.
Publicado: (2019)

Inhibition of sestrin 1 alleviates polycystic ovary syndrome by decreasing autophagy
por: Xu, Xiaoyuan, et al.
Publicado: (2021)

Dietary palmitate and oleate differently modulate insulin sensitivity in human skeletal muscle
por: Sarabhai, Theresia, et al.
Publicado: (2021)

Potential Roles of Sestrin2 in Alzheimer’s Disease: Antioxidation, Autophagy Promotion, and Beyond
por: Chen, Shang-Der, et al.
Publicado: (2021)

Adding GLP-1 Receptor Agonist Therapy to Basal Insulin for Postprandial Glucose Control
por: Rhinehart, Andrew S.
Publicado: (2015)

Future Perspectives on GLP-1 Receptor Agonists and GLP-1/glucagon Receptor Co-agonists in the Treatment of NAFLD
por: Seghieri, Marta, et al.
Publicado: (2018)

Sestrin 2 attenuates sepsis‐associated encephalopathy through the promotion of autophagy in hippocampal neurons
por: Luo, Lili, et al.
Publicado: (2020)

Palmitate-induced skeletal muscle insulin resistance does not require NF-κB activation
por: Hommelberg, Pascal P. H., et al.
Publicado: (2010)

Combination therapy with GLP-1 receptor agonists and basal insulin: a systematic review of the literature
por: Balena, R, et al.
Publicado: (2013)

Primary-care observational database study of the efficacy of GLP-1 receptor agonists and insulin in the UK
por: Hall, G C, et al.
Publicado: (2013)

Case Study: Use of GLP-1 Receptor Agonist in a Patient on Intensive Insulin Therapy
por: Wiley, Kenneth Calvin, et al.
Publicado: (2015)

Predictors of Responsiveness to GLP-1 Receptor Agonists in Insulin-Treated Patients with Type 2 Diabetes
por: Gavigan, Colleen, et al.
Publicado: (2023)

Excessive Autophagy Activation and Increased Apoptosis Are Associated with Palmitic Acid-Induced Cardiomyocyte Insulin Resistance
por: Li, Shanxin, et al.
Publicado: (2017)

Combination of basal insulin and GLP-1 receptor agonist: is this the end of basal insulin alone in the treatment of type 2 diabetes?
por: Moreira, Rodrigo Oliveira, et al.
Publicado: (2018)

Chronic Exposure to Palmitate Impairs Insulin Signaling in an Intestinal L-cell Line: A Possible Shift from GLP-1 to Glucagon Production
por: Filippello, Agnese, et al.
Publicado: (2018)

Favorable Appendicular Skeletal Muscle Mass Changes in Older Patients With Type 2 Diabetes Receiving GLP-1 Receptor Agonist and Basal Insulin Co-Therapy
por: Osaka, Takafumi, et al.
Publicado: (2023)

The Cardiovascular Effects of GLP-1 Receptor Agonists
por: Okerson, Theodore, et al.
Publicado: (2012)

GLP-1 Receptor Agonists and Kidney Protection
por: Greco, Eulalia Valentina, et al.
Publicado: (2019)

Clinical Trial Highlights – GLP-1 agonists
por: McFarthing, Kevin, et al.
Publicado: (2020)

GLP-1 receptor agonists (GLP-1RAs): cardiovascular actions and therapeutic potential
por: Ma, Xiaoxuan, et al.
Publicado: (2021)

Palmitate and oleate exert differential effects on insulin signalling and glucose uptake in human skeletal muscle cells
por: Mäkinen, Selina, et al.
Publicado: (2017)

Free Versus Fixed-Ratio Combination of Basal Insulin and GLP-1 Receptor Agonists in Type 2 Diabetes Uncontrolled With GLP-1 Receptor Agonists: A Systematic Review and Indirect Treatment Comparison
por: Jung, Han Na, et al.
Publicado: (2022)

AWRK6, a Novel GLP-1 Receptor Agonist, Attenuates Diabetes by Stimulating Insulin Secretion
por: Wang, Qiuyu, et al.
Publicado: (2018)

The Role of Glp-1 Receptor Agonists in Insulin Resistance with Concomitant Obesity Treatment in Polycystic Ovary Syndrome
por: Bednarz, Krzysztof, et al.
Publicado: (2022)

Combining GLP-1 Receptor Agonists and Basal Insulin in Older Adults with Type 2 Diabetes: Focus on Lixisenatide and Insulin Glargine
por: Handelsman, Yehuda, et al.
Publicado: (2019)

Correlation of asprosin and Nrg-4 with type 2 diabetes Mellitus Complicated with Coronary Heart Disease and the Diagnostic Value
por: Zhong, Min, et al.
Publicado: (2023)

Palmitic acid control of ciliogenesis modulates insulin signaling in hypothalamic neurons through an autophagy-dependent mechanism
por: Ávalos, Yenniffer, et al.
Publicado: (2022)

Stressin' Sestrins take an aging fight
por: Budanov, Andrei V, et al.
Publicado: (2010)

Sestrins at the crossroad between stress and aging
por: Lee, Jun Hee, et al.
Publicado: (2010)

Sestrin2 in diabetes and diabetic complications
por: Zhang, Xiaodan, et al.
Publicado: (2023)

Acute resistance exercise induces Sestrin2 phosphorylation and p62 dephosphorylation in human skeletal muscle
por: Zeng, Nina, et al.
Publicado: (2017)

Novel GLP-1 Fusion Chimera as Potent Long Acting GLP-1 Receptor Agonist
por: Wang, Qinghua, et al.
Publicado: (2010)

PPARγ Agonists Attenuate Palmitate-Induced ER Stress through Up-Regulation of SCD-1 in Macrophages
por: Ikeda, Jiro, et al.
Publicado: (2015)

Sestrin2-Mediated Autophagy Contributes to Drug Resistance via Endoplasmic Reticulum Stress in Human Osteosarcoma
por: Tang, Zhen, et al.
Publicado: (2021)

Correction to: Combining GLP-1 Receptor Agonists and Basal Insulin in Older Adults with Type 2 Diabetes: Focus on Lixisenatide and Insulin Glargine
por: Handelsman, Yehuda, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_trphfba9rbslblqlcd5d6qg516