Allopurinol non-covalently facilitates binding of unconventional peptides to HLA-B*58:01

Allopurinol, widely used in gout treatment, is the most common cause of severe cutaneous adverse drug reactions. The risk of developing such life-threatening reactions is increased particularly for HLA-B*58:01 positive individuals. However the mechanism of action between allopurinol and HLA remains...

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Detalles Bibliográficos
Autores principales: Huan, Xuelu, Zhuo, Nicole, Lee, Haur Yueh, Ren, Ee Chee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256732/
https://www.ncbi.nlm.nih.gov/pubmed/37296297
http://dx.doi.org/10.1038/s41598-023-36293-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10256732/
https://www.ncbi.nlm.nih.gov/pubmed/37296297
http://dx.doi.org/10.1038/s41598-023-36293-z

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